Association of Shorter Leukocyte Telomere Repeat Length With Dementia and Mortality
نویسندگان
چکیده
منابع مشابه
Association of shorter leukocyte telomere repeat length with dementia and mortality.
BACKGROUND Shortening of chromosomal telomeres is a consequence of cell division and is a biological factor related to cellular aging and potentially to more rapid organismal biological aging. OBJECTIVE To determine whether shorter telomere length (TL), as measured in human blood samples, is associated with the development of Alzheimer disease and mortality. DESIGN We studied available stor...
متن کاملChildhood Obesity Is Associated with Shorter Leukocyte Telomere Length
CONTEXT Obesity in adults is associated with shorter mean leukocyte telomere length (LTL), a marker of biological age that is also associated with age-related conditions including cardiovascular disease and type 2 diabetes. However, studies of childhood obesity and LTL have proved inconclusive. OBJECTIVE The objective of the study was to clarify the relationship between telomere length and ch...
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Recent studies have found mixed results regarding the association between leukocyte telomere length (LTL)--thought to be a marker of cellular aging--and all-cause mortality. Some studies have reported a significant inverse relationship, but others have not, perhaps in part owing to insufficient power. We examine the relationship using data from a nationally representative sample of older Taiwan...
متن کاملShorter Leukocyte Telomere Length in Midlife Women with Poor Sleep Quality
Background. Accumulating evidence supports leukocyte telomere length (LTL) as a biological marker of cellular aging. Poor sleep is a risk factor for age-related disease; however, the extent to which sleep accounts for variation in LTL is unknown. Methods. The present study examined associations of self-reported sleep duration, onset latency, and subjective quality with LTL in a community-dwelli...
متن کاملIs chronic asthma associated with shorter leukocyte telomere length at midlife?
RATIONALE Asthma is prospectively associated with age-related chronic diseases and mortality, suggesting the hypothesis that asthma may relate to a general, multisystem phenotype of accelerated aging. OBJECTIVES To test whether chronic asthma is associated with a proposed biomarker of accelerated aging, leukocyte telomere length. METHODS Asthma was ascertained prospectively in the Dunedin M...
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2012
ISSN: 0003-9942
DOI: 10.1001/archneurol.2012.1541